For instance, CBT might help identify maladaptive beliefs (“I can’t cope with stress without alcohol”) and reframe them. Motivational Interviewing can strengthen your resolve to adhere to TSM protocols when faced with temptations. Doesn’t Address All Underlying TriggersWhile TSM can block biochemical cravings, it doesn’t automatically resolve emotional trauma, social triggers, or environmental pressures fueling alcohol misuse. Combining TSM with therapy and lifestyle interventions is recommended. Moral and Cultural StigmaCertain communities or organizations only trust total abstinence.
How long does it take to reduce alcohol consumption after starting TSM?

This differs from daily use, where naltrexone is taken every day regardless of drinking, and the dosage may or may not be targeted. Ultimately, how you take naltrexone is a decision for you and your doctor to determine based on your needs and goals. This blocking effect includes naturally occurring opiates in the brain known as Endorphins. When alcohol is consumed, normally these endorphins are released, which causes the drinker to experience pleasure. When these receptors are blocked, the experience of the “buzz” is less when alcohol is consumed. Naltrexone has Drug rehabilitation been around for decades, first for opioid addiction, then for alcohol.
What “Evidence-Based” Really Means in Treatment
Unlike traditional abstinence-based methods, TSM does not require you to quit drinking immediately. Instead, it allows for a gradual reduction in alcohol consumption, giving individuals the flexibility to either moderate or work toward long-term sobriety. Many people who follow the Sinclair Method report life-changing results. Individuals often describe steady progress—less desire to drink, greater self-control, and improved relationships.
Key Takeaways
As a result, the enjoyment or “buzz” that alcohol provides can come back, which can lead to a return of previous levels of use. TSM is a powerful solution for those who want to regain control and moderate their drinking, offering a stress-free, sustainable approach without the pressure to quit entirely. If treatment with opioids is necessary, the naltrexone will need to be stopped for 2 to 3 days prior to starting the opioids. However, it was initially approved for the treatment of Opioid Dependence in 1984, because the medication works by blocking the effects of opioids.
- The individual must be committed to adhering to the plan’s guidelines.
- Alcohol consumption affects the brain’s reward system, triggering dopamine release that reinforces the desire to drink more.
- Taking naltrexone an hour before drinking prevents these endorphins from creating the pleasurable “buzz” that reinforces habitual drinking.
- The Sinclair Method is an affordable, realistic, and flexible treatment option that has a high rate of success.
The method also sinclair method does not address acute alcohol withdrawal or detox needs. Some individuals with liver conditions, opioid use, or certain psychiatric disorders may not be eligible. Additionally, emotional issues such as trauma, depression, or anxiety often require supplemental therapy for full recovery. Understanding these limitations helps set realistic expectations and supports more personalized treatment planning.

Traditional treatments for alcoholism, such as Alcoholics Anonymous (AA) and other abstinence-based programs, have been life-saving for many. These approaches typically involve a complete cessation of alcohol use, coupled with support from group meetings, counseling, and, sometimes, a spiritual component. While effective for some, this one-size-fits-all strategy does not accommodate the diverse experiences and needs of all individuals struggling with alcohol dependence. TSM is specifically designed for treating alcohol dependence, based on how alcohol stimulates the brain’s opioid receptors.
Who Can Benefit from The Sinclair Method?
If you want to stop drinking immediately, this method may not be for you. Seek help if drinking escalates, dosing becomes inconsistent, or mental health worsens. Get urgent care for severe withdrawal signs like seizures, confusion, or chest pain. It is important to note that medications for alcohol use disorder are the gold standard of addiction care and proven to be incredibly effective. However, there has also been relatively limited research on the use of this specific method. If naltrexone is taken consistently before drinking over the course of several months, it might cause “extinction,” which means that over time, an individual could lose the desire to drink entirely.
- Other side effects may include nausea, vomiting, loss of appetite, headache, dizziness, mood changes, difficulty falling or staying asleep, drowsiness, and muscle or joint pain.
- For many, this treatment method offers a practical path to drink less, feel better, and rebuild control without the alcohol deprivation effect.
- Always follow your healthcare provider’s guidelines regarding dosage, adherence, and potential drug interactions for optimal safety and results.
Naltrexone is an opioid antagonist, meaning it binds to and blocks opioid receptors in the brain — the same receptors that respond to endorphins released by alcohol. It ranges from mild to severe and includes patterns of alcohol consumption that lead to distress or harm. For many, drinking alcohol becomes habitual — not out of enjoyment, but out of compulsion, emotional dependence, or to avoid withdrawal. Sunnyside Med offers access to compounded naltrexone (50mg + B6 5mg), paired with behavioral tools to help you reduce your drinking over time.
